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When ketamine binds to NMDA receptors, an imbalance occurs between the release of dopamine, glutamate, and GABA

Improvements in fat metabolism and body composition tend to build over weeks

The specific mechanisms include: through multiple virulence factors such as lipopolysaccharide, gingipains, and butyrate, the subgingival biofilm synergistically enhances cellular susceptibility to ferroptosis across three pathways, namely iron metabolism, lipid metabolism, and antioxidant defense, thereby providing continuous fuel for the vicious cycle