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Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model
One of the most important effect of OPs is the inhibition of AChE, causing accumulation of acetylcholine at cholinergic synapses with excessive activation of muscarinic and nicotinic receptors and over-stimulation of cholinergic neurons, and also the production of cytokines and other pro-inflammatory molecules ( Organophosphorus pesticides increasing the mitochondrial calcium uptake, impairs complex I and II function and decrease electron transfer activities of cytochrome oxidase, and the activities of mitochondrial electron transfer enzyme, are responsible of lipid peroxidation, of 8-hydroxydeoxyguanosine formation and protein and mtDNA oxidation (Leung and Meyer, 2019)
Therefore it shouldn't lead to any side effects
Fang Zhu, Department of Entomology and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
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