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Thus, insulin resistance leading to elevated portal insulin levels may explain, at least partially, the overlap in individual IGF-I levels between older GH-deficient subjects and GH-sufficient subjects (85, 86)

GSH is at 110 mM concentrations in all mammalian tissues (highest concentration in liver) as the most abundant non-protein thiol that protects against excessive oxidative stress

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging

Ovarian granulosa cells regulate the accumulation of serotonin in oocytes through the uptake and degradation of serotonin by SERT and monoamine oxidase (MAO), respectively, and granulosa cells form a functional barrier that protects oocytes from exogenous serotonin and may play an important role in oocyte maturation and early embryonic development (Figure 3)