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2.14 IPA analysis Significantly differentially expressed genes, and corresponding Log 2 Fold Change values were imported to IPA bioinformatics software (Qiagen, Redwood City, CA, USA, Winter Release 2021)

The medication mechanism may still be appropriate, but vitamin D deficiency, zinc/B6 depletion, copper accumulation, elevated SAH, inflammation, poor sleep, hormonal change, toxic burden or medication interactions may have altered the biochemical environment

Sun, L., Wu, J., Du, F., Chen, X

Mechanisms of liver injury induced by smoking The detrimental effects of cigarette smoking on the liver are mediated through a complex interplay of toxic, immunologic, and oncogenic mechanisms