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Because the effect is GnRH-dependent , blocking GnRH abolishes kisspeptins LH/FSH response confirming it works by engaging the bodys own hypothalamic machinery [9]

FDA Regulatory Status The FDAs position is unambiguous: BPC-157 is not an approved drug for any medical condition

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The maintenance frequency approach offers middle ground where users completing intensive initial treatment (6-12 months daily) transition to reduced frequency (2-4 times weekly) maintaining copper supplementation at lower intensity and cost while avoiding complete discontinuation allowing some benefit decline