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In this regard, it has been shown that the pharmacological treatment with the classical estrogen receptor antagonist Fulvestrant (ICI-182,780) modifies the proliferative activity of NSPCs without affecting the differentiation toward the oligodendroglial lineage (Table 1)

Morphological changes in astrocytes of aging mice fed normal or caloric restricted diets

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Furthermore, a retrospective study on 30 patients of mean age of 13.93 years (12 - 17) with isolated meniscal tear showed a significant improvement of knee symptoms and daily activity according to Lysholm score 3 months after the PRP injection: from 3% of the patients having a good score to 76.7% of the patients having excellent and good outcomes after treatment 13