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In addition, many AMPs exhibit strong cytotoxicity on MDR tumor cell lines

Given the high structural conservation between CUL5s binding modes with RBX1 and RBX2 (83) found that neddylation-induced structural rearrangement of CUL5 facilitates its interaction with another key RBR-type E3 ligase, ARIH2, thereby activating the ubiquitin ligase activity of CUL5