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(c) Dominant lethal assays Negative results were reported in a test for dominant lethal mutations in ICR/Ha mice (expressed as an increase in early fetal deaths or, indirectly, by pre-implantation losses), after a single intraperitoneal injection of 13 or 16.5 mg/kg body weight or five consecutive daily oral doses of 5 or 10 mg/kg body weight

Its key advantage is high specificity for GH release without triggering ACTH or cortisol elevation, making it one of the safer GH secretagogues with minimal off-target hormonal effects [1] [3]

83 JiaY.CaoN.ZhaiJ.ZengQ.ZhengP.SuR.et al (2020)

Circadian Rhythms 19 , 2 (2021)