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Smoking is also associated with higher homocysteine levels.[ref][ref][ref] Folate and B12 status: In general, higher folate and vitamin B12 levels are associated with lower homocysteine levels.[ref] This association holds true with aging.[ref] Amount of methionine in the diet: Methionine is an essential amino acid found in protein-rich foods

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Peptides that act on the HPG axis include those that stimulate gonadotropin release indirectly via growth hormone or kisspeptin-modulating effects