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Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

Complexity in Patient Understanding and Compliance: Many patients struggle with foundational aspects of melasma treatment, such as effective photoprotection, proper sunscreen use, and understanding radiation sources like blue light, HEV, and infrared

Rapid improvement in blood glucose may temporarily worsen retinopathy in some patients

These effects typically resolve within the first week or two of use