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Avoid ethanol-rich systems that may destabilize the copper complex

These nanoparticles offer a range of advantages, including robust physical stability, resilience against environmentally sensitive and unstable drugs, demonstrated in vivo efficacy with strong cytocompatibility, effective penetration of lipid bilayers, and outstanding physical stability, making them a valuable choice for various applications [83]

Nihon Naika Gakkai Zasshi 78 , 14901491 (1989)

There was particularly damaged inner plexiform and inner nuclear layer, less thickness, along with complete retinal damage, less thickness, noted 1 week after L-NAME retrobulbar administration