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4 Research on disulfidptosis-associated CNS disease 4.1 Neurodegenerative disease 4.1.1 Alzheimers disease Alzheimers disease (AD) is a prevalent condition characterized by progressive degeneration of the brain, which may involve an increase in oxidative stress, a decrease in antioxidant enzymes, and consequent disruption of the redox dynamic balance (Yu et al., 2024)

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Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)

GltT was required for meningococcal survival within phagocytic cells (Tal et al., 2011) and in human whole blood (Li et al., 2009)