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However, a drawback of NP explants is that swelling pressure is no longer balanced by the AF and hyperosmolarity within the NP is difficult to maintain, which results in NP tissue swelling

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FOXO4-DRI has three main pharmacogenetic advantages: its stability (resistance to degradation by cellular proteases), half-life (compared to L-peptide equivalents, it's longer), and cell-penetrating properties (cell-penetrating sequences improve intracellular delivery)

Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model