Gene expression profile Continuous exposure to mercury resulted in the upregulation of several oxidative stress and inflammation-related genes, including MPO (4.55-fold, Table 2), HIF1 (4.31-fold, Table 3), MMP2 (4.20-fold, Table 4), TIMP1 (3.18-fold, Table 5), TIMP2 (4.83-fold, Table 6), NOS (3.52-fold, Table 7), and FN1 (3.52-fold, Table 8)
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The putative pantothenate transporter (PPT) was suggested to serve this role as it could complement the growth phenotype of a yeast mutant deficient in pantothenate transport ( tfp1 gene is dispensable (Zhang et al., 2018)
The activation of IDO1 enhances lipid peroxidation, which constitutes a pivotal event in the process of ferroptosis [219]