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By clearing senescent cells out, FOXO4-DRI reduces neuroinflammation and mitigates the stress on surrounding neurons

Chen J, Wang R, Zhang K, Chen LB

Geographically, the evidence is heavily concentrated in China and other East Asian countries, with minimal data from Western populations, which limits generalizability across ethnicities, healthcare systems, and regulatory contexts

MRI studies in individuals with T2DM have reported diabetes-related decreases in total GM and WM volume, as well as regional patterns of cerebral volume loss, including hippocampal involvement (101, 102)