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B12 injections may be more effective when low energy is due to B12 deficiency or impaired nutrient absorption, while NAD+ may support cellular energy, metabolism, and overall vitality

Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)

Patients are usually instructed to abstain from alcohol or smoking, as these may lower the efficacy of the antioxidant

To date, no severe adverse effects have been consistently documented in research settings