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While it inhibits fibrosis by activating the Keap1-Nrf2 pathway and downregulating the phosphorylation of Smad3 and STAT3, the interactions among involved signaling pathways (such as PI3K/Akt, MAPK, TGF-, Wnt/-catenin) and their roles at different pathological stages have not been systematically studied

The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione

It is naturally found in every cell of the body and plays a key role in reducing oxidative stress, enhancing immunity, and assisting in the removal of toxins from the liver

doi: 10.1016/0165-1781(95)02656-h 191