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Evidence discussed in this section is derived primarily from preclinical and mechanistic studies, including cellular systems and animal models, and should therefore be interpreted in a mechanistic rather than clinical context

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The influxing cystine consists of two chains: The light chain solute carrier family 7 member 11 (SLC7A11) and the heavy chain solute carrier family 3 member 2 (SLC3A2, also termed CD98), which are bound together by disulfide bonds (19,35,36)

Higher NAD+ levels activate SIRT1, a master regulator of metabolism, mitochondrial biogenesis, and fat oxidation