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5-Amino-1MQ (5-amino-1-methylquinolinium) is the most studied inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme that acts as a metabolic brake in fat cells by depleting both SAM (S-adenosylmethionine) and NAD+ precursors

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This makes supplements more similar to the natural kind of B12 in foods and a combination of methylcobalamin, adenosylcobalamin and hydroxocobalamin is considered ideal

Nicotinamide is a precursor of NAD+, the central cofactor of energy metabolism