Antidepressants, including tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine re-uptake inhibitors (SNRIs), show superior pain relief in IBS-C compared to placebo [120], with SSRIs also improving motility [121]

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BPC-157 modulates the nitric oxide system and suppresses specific inflammatory markers at the lesion site
GHK-Cu has been studied in the context of both