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28 days) improves cognitive function in the cognitive impairment model of aged rats, enhances synaptic plasticity in the hippocampus, and increases the expression of brain-derived neurotrophic factor (BDNF) [3]

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Furthermore, these nanosystems prolong uricase efficacy through immunomodulation, collectively highlighting the pivotal role of nanocarriers in enhancing drug bioavailability, targeting, and multi-pathway synergistic therapy