melanotic mucosa in colon Melanosis coli Brilliant Colonic Adenoma in Melanosis

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

The differences between the individual values of GSH content of liver determined in this assay were small, thus, confirming the literature report that GSH content of liver did not change when an animal was pretreated with microsomal drug-metabolizing inducers such as phenobarbitone, 3-methylcholanthrene and polychlorinated biphenyl (Arcolor 1254)

Green tea administration in ISO-administered rats significantly increased plasma catalase activity ( p 0.01) compared to ISO-administered rats (Fig

D., Bernier, M., Lpez-Lluch, G