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This stimulatory effect was also observed in primary cultures of human and mouse TEC when PRL (10(-7) to 10(-8) M) was applied to culture supernatants, thus suggesting that PRL could act directly on TEC

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By reducing IGFBP binding to negligible levels while preserving IGF1R affinity, LR3 enables sustained IGF1R activation in cell culture and in vivo models with practical dosing protocols