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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E

Bhattachar, S

Pathway analyses of differential genomic occupancy for both epigenetic marks showed enrichment in several inflammatory pathways, including TNF superfamily cytokine production, IL-6-mediated signaling, LPS-mediated signaling, Toll-like receptor signaling, cytokine production, type II interferon production and chemokine-mediated signaling (Extended Data Fig

Regulation of HSF1 function in the heat stress response: implications in aging and disease