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Glutathione S-transferase Glutathione -transferases (GST, EC 2.5.1.18), which first discovered as enzymes in 1961 [12], are abundant proteins encoded by a highly divergent, ancient gene family

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10,15,91 Of current interest is estetrol, which is a natural estrogen that spares the endometrium, while being an estrogen receptor agonist in the tissues, including the skin, that deteriorate following the loss of estradiol in the post-menopausal period

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