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By undermining barrier integrity, ferroptosis establishes a multilevel cascade involving iron overload, BBB permeability, and immune dysregulation, ultimately contributing to AD pathogenesis (Figure 4)

Shared Risk Factors Research consistently points to a handful of contributors: Family history of mood disorders, which raises risk for both conditions Trauma , especially in childhood, which is strongly linked to chronic depression in particular Chronic stress at work, in caregiving, or in financial or social conditions Substance use , which can precipitate, deepen, or mimic depression Medical conditions like hypothyroidism, chronic pain, and other systemic illnesses How Are MDD and PDD Diagnosed