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Their mechanisms are complementary rather than competitive, addressing different aspects of neural plasticity: Dihexa promotes the structural formation of new synaptic connections, while PE-22-28 enhances neuronal excitability and drives neurogenesis

The internal standard 2,3,3,3-d 4 -alanine, the derivatisation reagent methyl chloroformate (MCF), and pyridine were purchased from Sigma-Aldrich (St

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Fixation and Immunostaining Following completion of the incubation, cultures were fixed using 4% PFA for 25 minutes at room temperature or at 40 C