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Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers: Nrf2 degron-fused reporter system

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While older GHRPs like GHRP-6 and GHRP-2 stimulate growth hormone release but also spike cortisol, prolactin, and ACTH levels producing unwanted side effects ipamorelin triggers GH release with minimal impact on other hormones

By disrupting the FOXO4-p53 interaction, FOXO4-DRI, a specific FOXO4 blocker, selectively induced p53 nuclear exclusion and apoptosis in senescent Leydig cells