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Fas/FasL-mediated apoptosis pathway at the mitochondrial level Different triggers, including cytotoxic chemotherapy, UV radiation, the removal of growth factors, or the activation of p53, can lead to mitochondrial dysfunction followed by apoptosis

Examples include SCFAs like butyrate or propionate, which can be given orally or even intravenously [260]

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Discussion: Our findings suggest that CB-839 has limited efficacy in CLL treatment and shows limited synergy in combination with widely used CLL drugs