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Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo

As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures

Theriogenology (2012) 78(8):17008.10.1016/j.theriogenology.2012.05.002 32 GuerrieroGCiarciaG

By restoring telomerase activity in targeted ways, Epitalon may help preserve: Tissue regeneration capacity Stem cell viability Immune system responsiveness Genomic integrity Of course, telomerase activation is a double-edged sword: while it promotes healthy cell division, it can also fuel unchecked growth in malignant cells