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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

This dual functionality enables both stem cell pool expansion and directed differentiation depending on copper availability, providing remarkable versatility in regenerative applications

The activity of APX was calculated in terms of nmol of AsA oxidized per second

Although its tumoricidal properties hold therapeutic promise, its clinical application in lower gastrointestinal diseases and cancers remains challenging