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Chronic exposure changes brain chemistry which can result in dependence and withdrawal symptoms

Gasper : cigarette, fag (also of the 1920s) 23

All of those effects on the body add together to put smokers at a higher risk of many different medical conditions, including: Cancer Heart Disease Stroke COPD, Asthma Type 2 Diabetes Vascular Disease Eye Diseases Difficulties Conceiving (affecting both sexes) Reproductive health problems Birth Preterm Rheumatoid arthritis Smoking is a major risk factor for nearly every type of cancer