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Iqbal et al

Additionally, a study by Liu et al (41) demonstrated that miR-196a promotes the development of non-small cell lung cancer by downregulating the expression of GPX3 and activating the JNK pathway, thereby enhancing the proliferation, differentiation, self-renewal ability and invasiveness of cancer stem cells (CSCs) (41)

Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E

The reason is that L-Arginine is absorbed in the gastrointestinal tract and then transported to the liver where it undergoes rapid first-pass metabolism to other compounds leaving very little for the body to produce Nitric Oxide (NO)1