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3 Pharmacological profile 3.1 Antitumor activity Cancer progression is driven by dysregulated signaling pathways, including hyperactivation of oncogenes and inactivation of tumor suppressors, promoting uncontrolled cell proliferation, resistance to apoptosis, and metastatic spread ( 3.1.1 Effect on signaling pathways The existing studies of caudatins antitumor mechanisms involve the complex modification of multiple signaling cascades in variety of tumor models

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In vitro, qPCR was used to assess key gene expression in the control, DHT model, AS-IV, EP300 inhibitor (C646), and Nrf2 inhibitor (ML385) groups

The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin