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While metabolic biases differimpaired glycolysis in RA T cells versus enhanced glycolysis in MS and SLEthey converge on a common immunological phenotype: Th17 cell hyperactivation and Treg cell functional impairment ( Figure 2 )

Soon after stimulation by an appropriate triggere.g., chemokines/cytokines, pathogen components like lipopolysaccharide (LPS), and/or wounded tissueneutrophils migrate to areas of injury and/or infection and mount an initial innate immune response which requires a rapid metabolic switch dependent on G6PD

For needle-averse individuals, the convenience factor is substantial

documented practice is to return the vial to refrigeration promptly after drawing a dose