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Four alkaloids, namely arecoline (most potent), arecaidine, guvacine, and guvacoline were reported to stimulate fibroblasts to produce collagen, thought to represents the main pathogenic mechanism of oral submucous fibrosis (OSMF), a potentially malignant condition most common in Indonesia 7,8

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More needs to be done to urge decisionmakers at all levels, including entertainment executives and leaders of streaming platforms and broadcast networks, showrunners, directors, writers, actors, and music artists, to refuse to help normalize tobacco and eliminate it on screens most popular with young people