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Hence, FreSHtracer enables the monitoring and comparison of cellular GSH levels based on the observed fluorescence shifts

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Within the evolving TME, MDSCs are capable of shifting their phenotypes in response to metabolic cues from the surrounding tumor or stromal cells (hypoxia, lactate) and resistance mechanisms following standard chemotherapies or immunotherapies, further hindering consistent phenotypic identification and selective targeting

However, the brain is highly susceptible to oxidative damage due to its high oxygen consumption and limited antioxidant defenses (Sies et al., 2017)