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Western blot analysis RIPA Lysis Buffer (TransGen, Beijing, China) was used to extract total protein from tissues/fibroblasts and a Nuclear and Cytoplasmic Protein Extraction Kit (TransGen) was used to extract the protein from nucleus and cytoplasm of fibroblasts

BCR-ABL encodes a constitutively active tyrosine kinase that phosphorylates a panel of downstream targets to cause uncontrolled cell proliferation, protein synthesis, and anti-apoptotic signals 3,4,5,6

For example, Adriamycin under-goes redox cycling to produce quinone intermediates that provide a potent source of ROS

Cagrilintide had one of the lowest GI odds ratios among incretin-class compounds in a 2025 network meta-analysis, but combination GI burden has not been formally quantified