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Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis

Specifically, by utilizing a transgenic mouse model where a dominant negative IGF-I receptor is expressed specifically in skeletal muscle (MKR), it has been shown that increased mechanical load can induce muscle hypertrophy and activate Akt and p70S6K independently of a functional IGF-I receptor, implying that IGF-I may not be a limiting factor in the induction of hypertrophy with muscle overloading 61

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The injection of alcoholic extract of green tea at different dosages decreased significantly the activity level of ALT, AST and alkaline phosphatase liver enzymes compared with thioacetamide group