5, we showed that at various concentrations (5, 10, 25, 50, 100, 200 M), 4-OXO-DHA dose-dependently inhibited NF-B-DNA binding
Genetic deletion of Cd36 (encoding the oxLDL transportation protein CD36) increases the percentage of these stem-like T cells among tumor antigen-specific CD8 + T cells [64]
This increases the production of nitric oxide (NO), a potent vasodilator and signaling molecule that enhances blood flow and vessel permeability, further supporting tissue repair
The metabolites generated during metabolic reprogramming, including lactate and ROS, further impair local mitochondrial function, potentially exacerbating the energy deficit (69) and establishing a potential characteristic metabolic-inflammatory feedback loop in PEM