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Peripheral IRS activation, evidenced by increased plasma levels of TNF- receptor subtype 1, IL-6, and IL-8, is significantly correlated with atypical brain metabolism, cortical atrophy, diminished cortical gray matter, compromised integrity of white matter tracts in mood-related neural networks, and altered functional connectivity and activation patterns of cerebral circuits [1, 209]

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The evidence is unambiguous: seven-day dihexa protocols produce cognitive improvements measurable 30+ days post-treatment despite complete plasma clearance within 12 hours of the final dose