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(Kidney International 2022): Route : Chronic infusion in mice Models : STZ-induced type 1 diabetes and db/db type 2 diabetes Duration : Multiple weeks of treatment Outcomes : Reversed proteinuria, attenuated glomerular hypertrophy, mitigated podocyte damage, ameliorated fibrotic lesions Control : Scrambled-sequence KP6 showed no therapeutic effect Klotho Protein for Cognitive Enhancement# For the full KL1 domain (not KP1/KP6 peptides): In Castner et al

Even the paperboard used in food packaging (especially if it is recycled cardboard) can contain BPA, which is then transferred to the food we eat.[ref] Related article : BPA, BPS and detoxification pathways These estrogen mimics (at the levels found in people every day) have been linked to increased risk of several estrogen-related conditions, including: endometriosis[ref] enlarged prostate[ref] almost 2-fold increase in breast cancer for higher phthalate exposure (estrogen receptor-positive)[ref] BPA exposure at low levels is linked to increased breast and prostate cancer[ref] uterine fibroids[ref][ref] platelet reactivity and heart disease[ref][ref] We will cover more on how to avoid and eliminate these estrogen mimics in the Lifehacks section

it does not directly modulate systemic hormonal axes in research models