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Early research suggests they may influence neurotransmitter systems associated with stress and cognitive performance

44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops

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Hydroxocobalamin acts as a crucial cofactor in various metabolic processes, supporting the conversion of homocysteine to methionine, which is essential for DNA synthesis and cellular function