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Mitochondrial-derived ROS and mtDNA may activate signaling pathways like the NLRP3 inflammasome, which promotes the release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF-

Topaloglu R, Gultekingil A, Gulhan B, Ozaltin F, Demir H, Ciftci T, Demir N, Temucin CM, Yuce A, Akhan O (2020) Cystinosis beyond kidneys: gastrointestinal system and muscle involvement

This action was indicated by a decrease in inflammatory cytokines such as IL-1 and TNF- in the bronchoalveolar lavage fluid, suggesting that GHK-Cu may have an inhibitory action on these proinflammatory markers

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