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In contrast, solution from nicotine-free vape liquids (strawberry poptart and apple watermelon flavors) was shown to inhibit the activity of CYP2A6 (163).Together, these findings demonstrate both CYP isoform-specific and direction-specific effects following exposure to different electronic cigarette solutions

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186 After one extension, the comment period closed in July 2018 and the agency had received over 500,000 comments