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For example, older mice given nightly melatonin had levels of oxidative damage markers in brain and liver comparable to much younger mice, and they maintained better learning/memory performance than unsupplemented old mice ( In the context of healthy aging, melatonin supplementation is primarily discussed as a lifestyle-based strategy aimed at supporting sleep quality and circadian alignment in older adults

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Homocysteine can contribute to ROS production by activating NADPH oxidase

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