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Key scientific figures and citations Cagrilintide is a long-acting amylin analogue that, when combined with semaglutide, produced clinically meaningful and dose-dependent weight loss in adults with overweight or obesity. Enebo LB

Cellular and Molecular Neurobiology , 44(1), 1-16

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Unlike current single (GLP-1) and dual (GLP-1/GIP) agonist compounds like Semaglutide and Tirzepatide , Retatrutide is a triple agonist compound targeting three hormone receptors instead of only one or two: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) GCG (glucagon receptor) According to a landmark clinical trial published in the New England Journal of Medicine , Retatrutide demonstrated significant weight reduction, up to 30%, in participants over a 48-week period, highlighting its potential as a next-generation metabolic peptide