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These interventions aim to deliver targeted symptom relief directly within the joint space, with the principal agents including corticosteroids, hyaluronic acid (HA), and emerging biologics such as platelet-rich plasma (PRP) and cell-based products (Wehling et al., 2017

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These include host-related factors (e.g., immune response and cytokine profile), immuno-factors, drug pharmacokinetics (e.g., metabolism and adherence to treatment), and parasite-specific factors, such as genetic plasticity and co-infections (Figure 1)

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