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doi:10.1021/acs.jmedchem.1c00565 Eren S, Tonin G, Jurii Eren D, Klen J

J Natl Compr Canc Netw

Defined by hyperandrogenism, ovulatory dysfunction, insulin resistance, and chronic low-grade inflammation, PCOS, a common endocrine disorder in reproductive aged women causes irregular periods, infertility, excess androgens which collectively contributes toward long-term risks for serious conditions like type 2 diabetes, cardiovascular diseases, sleep apnea, depression, endometrial cancer and other reproductive complications underscoring the need for a comprehensive, multifaceted management strategy ( Figure 1 )

These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)