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Research overwhelmingly describes the safety of GHK-Cu positively, such as when the authors of a 2018 review called it a safe, inexpensive, extensively studied compound.14 However, even though copper peptides have demonstrated an impressive safety track record in studies, there are (as with most skin care actives) a few safety risks to consider

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It caused cytotoxicity at concentrations where other accumulating metabolites did not

Negative points: 4/54 Energy 0/10 points (8kJ) Energy intakes above energy requirements are associated with increased risks of weight gain, overweight, obesity, and consequently risk of diet-related chronic diseases